d@n: Hip-1 Hippi Hip-1 Hippi SIMI!!!!
Friday, April 20, 2007

Hip-1 Hippi Hip-1 Hippi SIMI!!!!

"Proposed model for Hippi/Hip-1 mediated apoptosis"
Hip-1 is normally bound and sequestered by wild-type Htt (polyglutamine (Q) <> 35 residues results in lower affinity for Hip-1, freeing Hip-1 to bind to Hippi. Hippi and Hip-1 form a complex that sequesters procaspase-8 and activates it, presumably by proximity-induced autocatalytic maturation, leading to apoptosis.

Hippi hip-1 Hippi hip-1 Hippi hip-1 Hippi hip-1~~~~~~ simi-1? sippi?

WORK THE FORK?

I HATE NEURO-friggin-BIO!!!!

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